|
KMID : 0892920150240020133
|
|
Experimental Neurobiology
2015 Volume.24 No. 2 p.133 ~ p.138
|
|
|
Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus
|
|
Yi Min-Hee
Zhang Enji
Baek Hyun-Jung
Kim Se-Na
Shin Na-Ra
Kang Joon-Won
Lee Sun-Yeul
|
|
|
Abstract
|
|
|
|
Growth differentiation factor 15 (GDF15) is, a member of the transforming growth factor β (TGF-β) superfamily of proteins. Although GDF15 is well established as a potent neurotrophic factor for neurons, little is known about its role in glial cells under neuropathological conditions. We monitored GDF15 expression in astrocyte activation after a kainic acid (KA)-induced neurodegeneration in the ICR mice hippocampus. In control, GDF15 immunoreactivity (IR) was evident in the neuronal layer of the hippocampus; however, GDF15 expression had increased in activated astrocytes throughout the hippocampal region at day 3 after the treatment with KA. LPS treatment in astrocytes dramatically increased GDF15 expression in primary astrocytes. In addition, LPS treatment resulted in the decrease of the IκB-α degradation and increase of the phosphorylation level of RelA/p65. These results indicate that GDF15 has a potential link to NF-κB activation, making GDF15 a valuable target for modulating inflammatory conditions.
|
|
|
KEYWORD
|
|
|
GDF15, Astrocyte, Excitotoxicity, NF kappaB signaling
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|